I can only say how I deal with some RPS issues for -my- fleets... what I didnt upload with the Wyan is the fleet support ships.. read 'Torpedo Resupply Ships'.
I keep a big pile of BV-mostly-neutral 'alternate loads' for the torpedo tubes, some AOE, some inverted range based damage, etc. Nothing so far as to be customizing a fleet against a given foe, but enough to reflect 'Hey, were on the bugswarm front, so we have AOE ammo' logical mentality.
Granted, fighters and strikers and seekers (though noone much uses seekers) ignore evasive action (why? We dont know why. Its like ignoring ECM, or applying to-hit penalties to certain weapons. Fighters are made of magic in every space battle game they appear in. But thats a different soap box). However, one can design anti-fighter weapons to fire through the penalties, or just bring enough interceptor style fighters of your own to deal with it.
And Beowulf.. you don't have to redesign your navy. I find it can be more rewarding to spend at least -some- time working out a tactical response to a tactical problem, rather than engineering a response to every perceived imperfection. If you swap out your screens for shields, you'll find your navy better against being swarmed (or AOE over-the-shoulder shots), but much worse at the 'holding range open and keeping shields maxed' game their designed to play.
That said, a more generalist design might be something you find more fun to play.
And yes, One-shot weapons oddly enough work better on large, barrage boat hulls than on small strike boat hulls. This is (logically) because the idea is that larger hulled boats, lasting longer, would get less relative value out of the ability to throw everything at the foe on the first round in range.
Unfortunately, the impact is to encourage 'refitted cargo ships' full of missiles, rather than the more fluffy missile armed strikeboats. (though a bunch of CR25 strike boats, armed with a nasty missile AND A POPGUN, can be awesome. The popgun, IMHO, is vital, as it keeps them a threat even after they shoot, complicating the opponents targeting choices)